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Established in 1907, Ruijing Hospital was originally called Guangci Hospital. It is today the largest clinical teaching base of the Shanghai Jiao Tong University School of Medicine, with about 1700 sick beds and a staff of over 3300 persons, among whom 507 persons hold senior titles. Each year it undertakes the teaching work for over 1000 medical students of different school systems and has become the cradle for training talents for medical circles.

The Hospital owns a large number of medical experts who enjoy relatively high celebrity both at home and abroad such as Chen Zhu, member of Chinese Academy of Sciences, Wang Zhengyi, Chen Saijuan, members of Chinese Academy of Engineering, and others. The hospital has 34 clinical departments, 7 departments of medical technology; 9 institutes (endocrionology, hematology, traumatology and orthopedics, burns, hypertension, digestive surgery, neurology, cardiovascular diseases, infectious diseases and respiratory disease); 11 laboratories, among which one is a State key laboratory (Key Laboratory of Medical Genomics), 2 key laboratories of Ministry of Public Health (Key Laboratory of Endocrine and Metabolic Diseases of Ministry of Public Health and Key Laboratory of Human Genome of Ministry of Public Health); 3 clinical medical centers (Shanghai Micro-Traumatic Surgery Clinical Medical Center, Shanghai Endocrine and Metabolic Diseases Clinical Medical Center and Shanghai Hematology Clinical Medical Center); 8 State bases for Clinical Research of Drugs; 3 key disciplines of State Ministry of Education, 6 key disciplines of Shanghai Education Commission and 3 leading disciplines of medicine of Shanghai Municipality.

In recent years, Ruijin Hospital has won over 300 scientific research projects of all kinds, including major projects of State Natural Science Fund, key projects, general projects, State Science and Technology Commission 863 Project, S863 Project, 973 Project, Climbing Program, State "8th 5-Year-Plan" Project for Tackling Key Problems and "9th 5-Year-Plan" Project for Tackling Key Problems, scientific research projects of Ministry of Public Health, State Education Commission Projects for Overseas Students, scientific research projects at the municipal level and other major projects.

In 2002 Ruijin Hospital has established the "Institute of Biologic Medicine", thereby forming a new pattern of large-scale scientific research and realizing the overall creation and innovation of scientific research system, employment system and scientific research etc.. This research institute takes the research strength of Ruijin Hospital as the main force, uniting such scientific research units as Shanghai Life Science Institute of Chinese Academy of Sciences, Health Science Center of the Shanghai Second Medical University and State South Center of Human Genome. It is the first research and development institution of taking the hospital as the principal part and integrating life science with clinical medicine. The employment principle of "seeking only the useful professionals instead of possessing the professionals" followed by the Institute truly embodies the "flexible flow" of the professionals, enabling more scientific research personnel to have a stage and space for showing their talent.