Structure-function studies of helicases
Recent publications
Ren H, Dou SX, Zhang XD, Wang PY, Kanagaraj R, Liu JL, Janscak P, Hu JS, Xi XG. The zinc-binding motif of human RECQ5beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme. Biochem J. 2008;412:425-33.
Guo RB, Rigolet P, Ren H, Zhang B, Zhang XD, Dou SX, Wang PY, Amor-Gueret M, Xi XG. Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res. 2007; 35:6297-310
Ren H, Dou SX, Rigolet P, Yang Y, Wang PY, Amor-Gueret M, Xi XG. The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling. Nucleic Acids Res. 2007; 35:6029-41.
Zhang AH, Bin HH, Pan XL, Xi XG. Analysis of p16 gene mutation, deletion and methylation in patients with arseniasis produced by indoor unventilated-stove coal usage in Guizhou, China. J Toxicol Environ Health A. 2007;70:970-5.
Xi XG. Helicases as antiviral and anticancer drug targets. Curr Med Chem. 2007;14:883-915.Review.
Zhang XD, Dou SX, Xie P, Hu JS, Wang PY, Xi XG. Escherichia coli RecQ is a rapid, efficient, and monomeric helicase. J Biol Chem 2006; 281:12655-63.
Hu JS, Feng H, Zeng W, Lin GX, Xi XG. Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc Natl Acad Sci U S A. 2005;102:18379-84.
Dessinges MN, Lionnet T, Xi XG, Bensimon D, Croquette V. Single-molecule assay reveals strand switching and enhanced processivity of UvrD. Proc Natl Acad Sci U S A. 2004;101:6439-44.
